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KMID : 1123920040180051471
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 5 p.1471 ~ p.1475
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Hair Growth Promoting Effect of Thuja orientalis Ethanol Extracts on Hair Loss-induced DBA1J Mice
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Kim Young-Jun
Chung Heon-Chul
Chung Hun-Taeg
Choi Kyu-Yoon
Yun Young-Gab
Jang Seon-Il
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Abstract
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Thuja orientalis extract (TOS) has been used on the hemostatic roborant, sedatives and stressless in oriental countries. We investigate the inhibitory effects on the productions of pro-inflammatory cytokines such as interleukin-1beta (IL-1β), IL-6, tumour necrosis factor alpha (TNF-α), and nitric oxide (NO) and the hair promotiont of TOS in the macrophage celline RAW264.7 or hair loss-induced DBA1J mice. T08 (50-500 ㎍/㎖) per se had no cytotoxic effect non-stimulated cells, but this extracts concentration-dependently reduced the release of NO, (IL-1β), IL-6, and TNF-α in the stimulate RAW264.7 cells with lipopolysaccharide (LPS). Moreover, when applied TOS (500 ㎍/㎖) to DBA 1J/mice, hair growth was promoted remarkably. These data suggest that T08 promotes hair growth on hair loss induced model mice and these properties may contribute to the anti- hair loss activity of the Thuja orientalis.
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KEYWORD
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huja orientalis, hair growth, RAW264.7 cells, pro-inflammatory cytokines, nitric oxide
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